In a recent study published in the prestigious Journal of Cataract & Refractive Surgery, theranostic-guided corneal cross-linking has been confirmed to induce precise and predictive corneal tissue strengthening in eye-bank human donor tissues through real-time measurement of the riboflavin corneal concentration during treatment.
The C4V CHROMO4VIS theranostic UV-A device used controlled UV-A light irradiation to induce both imaging and treatment of the cornea, providing a real-time measure of corneal riboflavin concentration and treatment efficacy (i.e., the theranostic score). The theranostic score showed high accuracy (94%) and precision (94%) to predict correctly samples that had improved tissue biomechanical strengthening (measured by air-puff dynamic tonometry), regardless of treatment protocol, i.e. with or without the corneal epithelium intact.